What inspired you to pursue science, and what discovery are you most proud of?
When I was in fifth grade in Zheleznogorsk, a remote Siberian “closed” town, my parents gave me a book that changed my life: a collection of biographies of great scientists. It showed me that there were other people who shared my fascination with science and mathematics. At school, I often felt lonely; few of my classmates were interested in physics or biology.
Another turning point came entirely by chance. I learned about the Krasnoyarsk Summer School, organized by students and professors at Krasnoyarsk State University who were passionate about science education. I found myself at a summer camp on the banks of the Yenisei River, surrounded, for the first time, by children my age who loved science as much as I did.
There I also learned about the Moscow Institute of Physics and Technology, known as MIPT or “Phystech,” a legendary institution for physics and mathematics. Several of our instructors were MIPT students, and I dreamed of becoming one of them. Two years later, that dream came true. I went on to receive my bachelor’s, master’s, and doctoral degrees through Phystech.
I am particularly proud of my work on phase singularities induced by virtual electrodes in the heart. Today, the word “singularity” often appears in predictions about artificial intelligence and a technological transformation of humanity. My work concerns a very different, precisely defined physical phenomenon of singularity.
A phase singularity lies at the center of a rotating wave of electrical activity. In the heart, these waves can resemble electrical tornadoes, disrupting the coordinated contractions needed to pump blood. They play an important role in dangerous arrhythmias, including ventricular fibrillation.
Using an advanced optical mapping system I built at the Cleveland Clinic, I observed how an electrical shock could disrupt the heart’s normal electrical activity and generate these rotating waves. A key mechanism involves the interaction of an applied electric field with variations in the heart’s tissue, including scars. These interactions create regions of electrical polarization — “virtual electrodes” — that can give rise to phase singularities.
More broadly, this work showed how an external field interacting with local differences in an active medium can produce a profound disruption — a singularity — of its behavior.
I sometimes see an analogy with societies: internal polarization, combined with disruptive external forces, can produce devastating instability and war. That is a metaphor, of course, rather than a scientific theory of society.
What matters more in science: intelligence, perseverance, intuition, or luck?
Chance favors the prepared mind. Scientific discovery requires openness to the unexpected and the ability to see familiar facts from a new angle. Intelligence, perseverance, and intuition all matter, but so does recognizing an opportunity when luck presents it. A scientist must be open to serendipity.
Conversely, rigid adherence to tradition or an established paradigm can be one of the greatest obstacles to discovery.
Have you ever spent great effort pursuing a hypothesis that turned out to be completely wrong?
Yes. Being wrong about a hypothesis is a normal part of a scientist’s life. Hypotheses exist to be tested, and we must be willing to abandon them when the evidence demands it.
Unfortunately, the scientific establishment has often treated hypothesis-driven research as a requirement to confirm the original hypothesis. Journals and funding systems tend to reward positive results, while negative findings receive far less attention and are often not even considered for publication.
This creates fertile ground for false discoveries. Researchers may be misled by false-positive results, whether through honest error, selective interpretation, or deliberate misconduct. Others then spend years — and sometimes billions of dollars — trying to develop therapies or technologies based on findings that cannot be reproduced.
Once a reputation is built around a theory, abandoning it can become personally difficult. Some scientists defend such claims for decades. In rare but highly publicized cases, investigations uncover fabricated data and lead to the retraction of influential papers.
These failures waste resources, obstruct reliable research, and erode public trust. Science depends on our willingness to accept an unwelcome result, including the discovery that we were wrong.
What is the greatest unsolved mystery in your field?
Bioengineering is full of unanswered questions. How far can we extend the human lifespan? Is immortality even conceivable? Why do women generally live longer than men?
Can we regenerate damaged hearts or engineer replacement organs? Can we build a bionic organ that combines living tissue with electronics? How do organs sense their surroundings, process biological information, and adapt to injury?
And as artificial intelligence develops, should we integrate it with our minds — and, potentially, with our sense of identity?
These questions reach beyond engineering into biology, medicine, and philosophy.
Is AI going to revolutionize biomedical research and eventually replace scientists?
AI — and machine learning in particular — has been part of scientific research for decades. I wrote my first neural-network program in the 1980s, hoping to detect the onset of an arrhythmia from an electrocardiogram in real time. It did not work; the computing resources available to me were far too limited. Today, related methods can identify many arrhythmias and extract information from an ECG that may not be apparent to a physician, including estimates of a patient’s age and sex.
But biomedical research requires more than analyzing existing data. A physician must examine and care for a living patient. An experimental scientist must interact with the physical world through instruments and measurements. Many major discoveries begin with a new instrument or method that makes something previously inaccessible measurable.
AI will help us design experiments, analyze data, and recognize patterns. Increasingly, it will also work with automated laboratory systems. Yet deciding which questions matter, developing new ways to investigate them, and interpreting results in their biological context will continue to require human judgment and human hands.
I expect AI to transform the work of scientists. Replacing scientists is a much larger claim.
What prompted you to leave Russia, and have you ever regretted that decision?
I left Russia in 1992 because the choice, as I saw it, was to leave science or leave the country. Scientific funding collapsed under Yeltsin’s government. My wife, who is also a scientist, and I each earned the equivalent of about six dollars a month. We could not support our family.
I have never regretted that decision. It gave me the opportunity to work in what I consider the strongest scientific culture in the world: the American research community.
Very few of my classmates who remained in Russian science were able to build the careers their talents deserved. Some who left science for business became highly successful. But business was never the life I wanted. I wanted to remain a scientist.
What did Soviet or Russian scientific education teach you that American education did not?
For me, the defining strength of the Moscow Institute of Physics and Technology was its approach to problem-solving. It provided rigorous training in physics, mathematics, programming, and English, but its most valuable lesson was how to approach an unfamiliar scientific problem.
A Phystech graduate left with the confidence that a new field could be learned, and a difficult problem could be broken down and understood.
Over my career, my interests have ranged from genetics and nuclear physics to computer science, cardiac physiology, and bioelectronics. These are very different fields, but the intellectual foundation I acquired at Phystech allowed me to explore and enjoy all of them.
Is scientific research truly free from politics, money, professional jealousy, and personal ambition?
No. Scientists feel the effects of America’s political cycles acutely. Together with Anna Krylov and other colleagues, I have written about politicization and counter-politicization in research funding under both Democrats and Republicans.
The ivory towers of elite universities offer little protection when politicians seek to impose their ideologies on education and research. Professional rivalries, personal ambition, and failures of academic leadership can make universities more vulnerable to these pressures.
Science has long benefited from broad public trust and bipartisan support. The erosion of that support threatens America’s leadership in science and technology.
What is your view on scientific dishonesty, censorship, or political interference in research?
All three undermine the conditions that make science possible: intellectual honesty, open inquiry, and the freedom to follow evidence wherever it leads.
My colleagues and I have addressed these issues in articles written during both the Biden and Trump administrations. Political interference is damaging regardless of which party practices it.
Failures of scientific integrity also weaken public trust, particularly when prominent researchers receive substantial funding and accolades for work that later proves unreliable. Meanwhile, expanding academic bureaucracies can burden research with ideological requirements and restrictions.
Science has traditionally relied on criticism, replication, and professional reputation to correct its mistakes. Those mechanisms still matter, but they do not always work as they should. We need serious reflection on how to strengthen them.
Russia lost many of its greatest scientific minds through emigration. Can that loss ever be reversed?
The departure of talented scientists from Russia has a long history. The biologist Ilya Mechnikov left before the revolution. Here in Chicago, I live on the very site where the Russian chemist Vladimir Ipatieff lived from 1930 to 1952. He conducted research and taught at Northwestern University. Almost a century later, I am doing the same.
Talented people will continue to be born everywhere, including Russia. The difficult task is building institutions in which their talent can flourish. I tried to help strengthen Russian science during the 2000s and 2010s and co-founded the Russian American Science Association (RASA) to help build democratic scientific institutions in Russia.
The current regime of the Russian Federation destroyed these efforts, named me a “foreign agent,” and declared RASA an “undesirable organization.” That experience left me deeply skeptical about the possibility of restoring institutions damaged under Yeltsin and Putin in my lifetime.
Germany’s experience illustrates how lasting such damage can be. The destruction of its scientific community under Hitler ended an era of extraordinary leadership. Rebuilding laboratories is one thing; rebuilding a culture of intellectual freedom and trust is another.
I do not expect to see Russia return to the world’s top ten scientific nations in my lifetime.
Do you consider yourself a Russian scientist, an American scientist, or simply a scientist?
Science belongs to humanity, not to any one country. Its centers of leadership have shifted over the centuries, and its progress has always depended on ideas crossing borders.
I collaborate with researchers around the world and teach students from many countries. In that sense, I am simply a scientist. I am also an American citizen, grateful for the opportunities this country has given me.
Are Nobel Prizes and other prestigious awards always given to those who genuinely deserve them?
The more difficult question is whether everyone who deserves recognition receives it.
The Nobel Prize was established in an era when a major discovery could more readily be associated with an individual scientist. Even then, research depended on collaborators and trainees. Today, science is even more clearly a team effort.
Limiting a scientific Nobel Prize to three people inevitably leaves out researchers who may have made equally important contributions. Those selected may fully deserve the honor, while others deserve it just as much.
Awards recognize achievement, but they cannot provide a complete or perfectly fair account of how discovery happens.
What has your scientific career taught you about human nature, mortality, and the meaning of life?
Reading the biographies and writings of scientists from past centuries has taught me how little human nature has changed. We are driven by many of the same passions, failings, and impulses toward kindness as people who lived five hundred years ago.
Science has changed the conditions of our lives enormously. Applied through medicine, it has helped us live longer; applied through technology, it has improved our quality of life. Yet our fundamental human concerns remain familiar.
My own experience has taught me to find meaning and joy in everyday life: working on a scientific problem, teaching students, developing a technology that might save lives, and talking with my children and grandchildren.
If you could start your life over, would you choose the same career and the same country?
In 1900, my great-grandfather Grigory Tololo moved his family from the Poltava region to Siberia, where the Russian government offered land to settlers. He could have chosen America, as many Ukrainians did at the time. Instead, he chose Siberia.
That decision shaped the lives of several generations of my family. My grandmother and mother endured collectivization, hunger, and backbreaking labor. Several family members died during the Second World War, which I see as a catastrophe brought about by Hitler and Stalin. I was born and raised in a city surrounded by barbed wire and built by Gulag prisoners.
By moving to America, I changed the course of that family history. I wanted my children and grandchildren to have a future free from another century of rule by the KGB and its successors.
Yes, I would choose science again, and I feel fortunate to live and conduct my research in the United States.